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Norvasc online pharmacy. By contrast, for some Kamagra oral jelly original bestellen of the other drugs, there was strong evidence for a reduced risk, although the magnitude of risk could not be quantified. These findings suggest that although not conclusive, the data do show that there may be no increased risk of myocardial infarction that is attributed to the drugs used. Introduction The relative safety of antidepressants in people who take them to help feel better, has been a long-supported concept and one that patients their doctors have often wanted to see confirmed.1 However, despite this, antidepressants had been implicated in a small proportion of reported cases ventricular arrhythmia2 and as a risk factor for stroke and heart failure.3–5 The finding that antidepressants may sometimes produce transient arrhythmias led to the introduction of drugs with slightly increasing proarrhythmic properties like benserazide6 and alemtuzumab7 as first-line agents for depression. This new indication their use brought with it the expectation that many patients would continue to take the medication after their benefit had worn off and the risk of death disability increased in the process.4,8 This article is concerned with a potential increased risk of myocardial infarction that has not been clearly established. This article uses updated statistics for the drugs of class amitriptyline, pimozide, quetiapine and clomipramine (the 4th-generation drugs of imipramine, nortriptyline and desipramine) that are known to cause temporary arrhythmias.9 These are included in a recent meta-analyses reporting on the potential risk of myocardial infarction among people taking antidepressants.7,10,11 The studies used different methods for determining whether the arrhythmias occurred and in many these studies, the duration of time between patients' enrolment and the time of symptom onset was not specified. Nevertheless, these studies are consistent in showing an increased incidence of ventricular arrhythmias (defined as an unprovoked ventricular tachycardia on electrocardiogram) associated with antidepressants.7,10,11–14 Although no specific study exists on this topic, the risk of a death attributable to antidepressants has been estimated as 2 per 1 million people in the general population.14–16 This article presents updated information on these arrhythmia rates, using the best available data. We also present our findings in meta-graph form to help illustrate the risks of antidepressants.

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